The Somatostatin Analog 188Re-P2045 Inhibits the Growth of AR42J Pancreatic Tumor Xenografts

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The somatostatin analog 188Re-P2045 inhibits the growth of AR42J pancreatic tumor xenografts.

UNLABELLED P2045 is a peptide analog of somatostatin with picomolar affinity for the somatostatin receptor subtype 2 (SSTR2) upregulated in some pancreatic tumors. Studies were conducted in rat AR42J pancreatic tumor xenograft mice to determine whether (188)Re-P2045 could inhibit the growth of pancreatic cancer in an animal model. METHODS (188)Re-P2045 was intravenously administered every 3 d...

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ژورنال

عنوان ژورنال: Journal of Nuclear Medicine

سال: 2014

ISSN: 0161-5505,2159-662X

DOI: 10.2967/jnumed.114.140780